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Royal gala apples grown in a Plant & Food Research greenhouse. Left, Fruit with an additional apple gene to make it red throughout. (Photo: Supplied / Plant and Food Research)
Royal gala apples grown in a Plant & Food Research greenhouse. Left, Fruit with an additional apple gene to make it red throughout. (Photo: Supplied / Plant and Food Research)

ScienceNovember 20, 2018

‘The core technology of the future’: Time to rethink NZ’s GMO-free status?

Royal gala apples grown in a Plant & Food Research greenhouse. Left, Fruit with an additional apple gene to make it red throughout. (Photo: Supplied / Plant and Food Research)
Royal gala apples grown in a Plant & Food Research greenhouse. Left, Fruit with an additional apple gene to make it red throughout. (Photo: Supplied / Plant and Food Research)

Trees with red trunks and apples that are red right the way through and flower all year round. Should we back or block the genetically changed plants New Zealand scientists are growing? Charlie Dreaver reports for RNZ.

At a Plant and Food Research greenhouse in Auckland, one of the sections is filled with $300 apple trees, and Andy Allan, a professor of plant biology, is pointing out one of his favourite experiment, a tree with bright, fuchsia-coloured flowers.

“The particular red gene we’re testing is under a strong expression, so the roots are red, the trunk is red, the leaves are copper and the fruit goes on to look more like a plum, it’s so dark.”

The apple has an extra apple gene, making it genetically modified. There are other plants in this room that have exactly the same number of genes, but they’ve been edited.

Along with the apples, pears, tomatoes and petunias are thriving, but many also flower all year round and produce seeds five years earlier than usual.

Allen compares the practice of gene editing in plant breeding to key-hole surgery.

“It just makes a cut in a place you know exactly where it’s going to go to. That cut is repaired by the plant, but often the plant makes a mistake, but those mistakes are like the natural equivalent to mutation and variants you see out there in the environment.”

He says the public’s perception of the research is much more sinister than what actually happens.

“We are academics or public civil servants and we’re doing experiments using the plant’s own DNA, so the perception of what we do as being evil or dangerous, is way different than what actually happens in this greenhouse.”

Professor Andrew Allan pollinating an apple tree, as bees aren’t allowed in the research greenhouse. (Photo: Supplied / Plant and Food Research)

Other countries would plant these crops in the field, he says, and he believes some of those growing in the greenhouse are ready for the outside world.

“I think these plants are as safe as the normal plants are, there is risk associated with everything, but there are no additional risks associated with these plants.”

And the benefits of what’s being grown could be significant, he believes, including trees which would not need cooler winters to flower and grow fruit.

But everything that leaves the facility, even the soil, will have to be destroyed.

“The only thing exiting this greenhouse at the moment is knowledge.”

Farmers divided

Parts of the farming community say they should have choice over whether to use GMOs or not.

But others, including the minister for the environment, David Parker, argue there is no need to jump the gun on introducing GMOs into the environment.

In his last report as chief science advisor for the prime minister, Sir Peter Gluckman laid out the ways genetic modification or gene editing can benefit the agricultural sector with pasture management and emissions.

“New Zealand scientists have developed promising forages using genetic technologies that could be used to make major progress through higher energy, lipid rich rye grasses which are now in field trials in the United States.

Flowers on a genetically modified apple tree (Photo: Supplied / Plant and Food Research)

“However, these have not been and effectively cannot be subjected to field testing in New Zealand.”

He said New Zealand needed to revisit the contentious topic.

“We have such big challenges ahead of us, between environmental degradation, climate change, the future of agriculture, the future of New Zealand’s economy, the way we live, the way rural life and provincial life occurs.

“This is the core technology of the future, alongside the digital technologies and precision agriculture, we can’t afford not to have the conversation.”

GM and the law

At the moment, all applications to release GMOs, need to be approved by the Environmental Protection Authority.

Since that change was written into the act 1996, coming into force two years later, only three GMOs have been approved – a vaccine for equine flu, and two cancer therapies for clinical trial.

The Act was reviewed in 2015, but no real differences were made for those scientists and industries interested in GM and GE.

Gene editing, which uses the DNA already existing within the organism, falls under the same legislation as genetic modification, which some scientists argue is different.

Since the act was introduced there have been new technologies such as the CRISPR technique created in 2012, which involves editing parts of the genome by removing, adding or altering sections of the DNA.

Legal and Scientific researcher Dr Julie Everett-Hincks, from the University of Otago, believes legislation is due for an update.

“They didn’t even contemplate this technology back then, there have been some minor edits since then, but really with this new technology it’s trying to work out where it fits.

“And you could argue that under the current legislation that it’s having difficulty fitting, so a review with differently needed.”

But Pure Hawke’s Bay – which was instrumental in the move to make the Hastings District Council adopt a 10 year moratorium on genetically modified crops – says business would suffer if any changes were allowed and they argue that not enough is known about the technology and its effects.

Its chair, Bruno Chambers, says there are other options to investigate in order to lower emissions, which will not require GM.

“We’re not anti-science and if something came along that was genetically modified that was really going to offer huge benefits to a number of farms, then we’d be looking at it with an open mind, but it always comes back to the markets.”

Chambers believes there would be an impact on the market if New Zealand crops were no longer GM-free.

“People are just starting realise how important it is for the New Zealand brand, it’s a critical part of our selling position.”

In Europe, 64 regional governments have declared themselves genetically modified organism free.

And earlier this year, the European Court of Justice ruled gene editing, is still GM and would need to be labelled as such, and would adhere to the same rules.

Environment minister David Parker (Photo: RNZ / Richard Tindiller)

An orchardist in the region, David Cranwell says having GM in New Zealand will have an impact on where he can sell his apples.

“The company I work with, it’s one of the biggest supermarket chains in Europe. They will not touch any genetically modified product, so if you’re genetically modified you don’t actually have access to sell through their stores, end of story.”

There’s also resistance to any change at this stage from the government.

David Parker agrees with the European Courts decision to include GE under genetic modification rules and has no intention of changing the legislation here.

“It takes a precautionary approach, people who want to make an application to release the GMO can, that’s then dealt with by the regulator and we think the law is fit for purpose.

“I’d have to be satisfied there was a need to change the law, and I’m not satisfied.”

He also highlights the trade benefits in keeping crops GM-free.

“Sometimes they might be overstated, but none the less they are real.”

If there are to be any changes in the use of GM, Parker says the government will first be looking at pest control, rather than agriculture.

This article was originally published on RNZ.

Keep going!
How it feels. Photo: Getty
How it feels. Photo: Getty

ScienceNovember 17, 2018

Science or Snake Oil: do hangover cures actually work?

How it feels. Photo: Getty
How it feels. Photo: Getty

It seemed like a good idea at the time. But a few drinks with friends turned into a few more, and the next morning you’re not feeling so crash hot. Is there anything you can take to help? Ken Harvey of Monash University and Paulina Stehlik of Bond University look at the evidence 

Over recent years, a number of products have emerged that claim to prevent or cure hangovers if consumed while drinking and/or the morning after. Five products are now marketed in Australia: Rapid Recovery, Recoverthol, Rejoove, Hydrodol and Body Armour.

These products contain various combinations of:

  • Vitamins – B1 (thiamine), B2 (riboflavin), B3 (nicotinamide), B5 (calcium pantothenate), B6 (pyridoxine), B12 (cyanocobalamin) and C (ascorbic acid),
  • Cysteine – an amino acid and
  • Herbs – silybum marianum (milk thistle), pueraria lobata (kudzu root) and hovenia dulcis (Japanese raisin tree).

The smallest number of ingredients in a product was three, the average 15 and the most 33. Clearly, there is little consensus on what ingredients work.

Vitamins and amino acids

We found one recent systematic review that assessed six interventions for the prevention or treatment of hangover.

One study reviewed a French product (After‐Effect©) that included vitamins B1, B6, and C, but also had many other ingredients. The results were reported as promising, but the study lacked a placebo arm, which means it wasn’t compared with a “dummy” pill. In addition, one of the authors was president and founder of the company that produced the product, while the other was a consultant.

There is a small published post-marketing evaluation of one of the Australian hangover products. This product contained three vitamins and one amino acid. This study also had many limitations.

In short, we found no evidence from robust clinical trials that supplementation with vitamins and amino acids prevents or reduces hangover symptoms.

Enjoying a few drinks can come with a price the next day.
Kelsey Knight/Unsplash

What about herbs?

Silybum marianum (milk thistle) has been used traditionally for liver problems. However, there is no evidence supporting these traditional claims.

Pueraria lobata (kudzu root) inhibits aldehyde dehydrogenase, the enzyme that breaks down acetaldehyde. This increases toxic acetaldehyde levels that are thought to be largely responsible for hangovers; the opposite of what a hangover remedy should do.

This action is the same as produced by disulfiram (Antabuse®), a medication used to treat alcohol dependence by producing severe hangover symptoms immediately after alcohol is consumed (aversion therapy).

Researchers have suggested medicines containing kudzu root should have similar warnings to those provided for disulfiram. The same paper was also concerned that the use of kudzu root in hangover remedies may increase the risk of acetaldehyde-related cancer of the oesophagus, oropharynx, and nasal passages in genetically predisposed individuals, especially if combined with chronic alcohol and smoking habits.

Hovenia dulcis (Japanese raisin tree) was used in one randomised controlled trial that explored the effect of this ingredient in alleviating hangover symptoms in 26 males. The researchers evaluated 14 hangover symptoms and found those who took a standardised preparation of Hovenia dulcis were less likely to report headaches, dizziness and weakness than those who took the placebo.

But this study has a number of limitations. It used a small sample size; it included no women participants; it tested only one type of alcohol, Korean Soju; and the study period was short, just 12 hours. These results need replication with a larger number of mixed sex and age subjects and a variety of alcohol preparations.

In addition, the two Australian products that contain Hovenia dulcis do not appear to contain the standardised extract used in the above small trial and the amount varies: Rejoove) 75 mg (2 tablets recommended); (Body Armour 30 mg/mL (100 ml recommended).

Sorry folks, there’s still no proven cure for a hangover – though it can, of course, be prevented by drinking in moderation or avoiding alcohol.
The Conversation

Ken Harvey is Associate Professor, School of Public Health and Preventive Medicine, Monash University. Paulina Stehlik is Senior research fellow, Bond University

This article is republished from The Conversation under a Creative Commons license. Read the original article.